Innate cellular responses to rotavirus infection

Cellular responses to enteropathogenic Escherichia coli infection.

Enteropathogenic Escherichia coli (EPEC), first described in the 1940's and 1950's, remain an important cause of severe infantile diarrhoea in many parts of the developing world. EPEC do not produce enterotoxins and are not invasive; instead their virulence depends upon exploitation of host cell signalling pathways and the host cell cytoskeleton both as a means of colonizing mucosal surfaces of...

Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice.

The purpose of the present study was to develop a quantitative assay that could be used to measure the local and systemic immune responses to specific rotavirus proteins following rotavirus infection of adult mice. To measure these responses, we used an immunocytochemical staining assay of Spodoptera frugiperda (Sf-9) cells which were infected with recombinant baculovirus expressing selected ro...

Advances in dissecting mosquito innate immune responses to arbovirus infection.

Arthropod-borne viruses - arboviruses - are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In this review, we discuss novel findings in the field of mosquito antiviral responses to arboviruses, in particular RNA inter...

Innate Immune Responses in HIV-Infection

The immune system comprises complex cellular and humoral systems, which are forming an interactive network to recognize and eradicate invading pathogens. Foreign molecules present on viruses, bacteria and parasites, but not on host cells, are discriminated from self through pathogen-associated molecular patterns. Upon entry of the pathogen into the body immediate non-specific immune responses a...

Early Response to Rotavirus Infection